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William Harvey Research Institute
Centre for Clinical Pharmacology
We seek two bioinformaticians to contribute to the delivery of high-quality research under the supervision of Dr. Damian Smedley.
As a member of our team, you will contribute to the analysis and presentation of findings from the International Mouse Phenotyping Consortium (IMPC). The IMPC is a successful collaboration of some 20 institutes world-wide that aims to produce the first comprehensive, functional catalogue of a mammalian genome by systematic phenotyping of mouse knock-outs for every protein-coding gene in the mouse. The NIH-KOMP3 grant that funds the majority of this work was recently renewed for ~$100m over the next 5 years, including the informatics component (MPI2) consisting of teams at the European Bioinformatics Institute, MRC Harwell and QMUL. MPI2 is responsible for all data collection, QC, and analysis of the phenotypes as well as the presentation of the results on the IMPC portal. The postholder will be responsible with other members of the QMUL team for the maintenance and improvement of the human disease association pipeline as well as other research projects to investigate how the phenotypes relate to protein function, pathways, disease mechanisms and potential therapeutic interventions for patients containing disruptions of the same genes. There will be strong interactions with other members of the team that are funded through the Monarch Initiative to collaboratively develop the phenotype similarity algorithms that underlie much of our IMPC work as well as the Exomiser and Genomiser software suite of phenotype-aware variant prioritisation software being used in many large scale disease sequencing studies such as theGenomes Project. Dr. Smedley holds a joint position as Director of Genomic Interpretation at Genomics England that is delivering theGenomes Project and a major focus is on functional validation through IMPC resources of candidate variants from NHS patients enrolled in the project.
The Centre is part of the world renowned William Harvey Research Institute (WHRI). In UK Research Assessment Exercise inf WHRI faculty were rated as world leading or internationally excellent and our Medical School was ranked amongst the top 5 in the UK (). We have recently joined University College London Partners Academic Health Sciences System which extends our reach to 5 million people and have recently joined the Russell Group of top research intensive UK Universities.
The Centre offers newly refurbished laboratories, cutting edge facilities and is located in the heart of the City of London in close proximity to the Barbican Arts and Music Centre.
The post is full time and on a fixed term contract for 4 years in the first instance. The starting salary will be £pound;per annum inclusive of London Allowance. Benefits include 30 days annual leave, defined benefit pension scheme, interest-free season ticket loan and family-friendly working.
Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality ActWhere required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.
Informal enquiries about this post are welcome and can be made to Dr Damian Smedley ().
Details about the William Harvey Research Institute can be found on .
Application enquiries should be directed to .
To apply, please visit the Human Resources website on and search for reference QMUL10627.
The closing date for the applications is on the 12 March 2017 and interviews will be held shortly thereafter.
Valuing Diversity & Committed to Equality
Please click on the link below for more information about this role:
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